Article
Preventing fibril formation of a protein by selective mutation.
Proceedings of the National Academy of Sciences of the United States of America - 3 Nov 2015
Maisuradze Gia G, Medina Jordi, Kachlishvili Khatuna, Krupa Pawel, Mozolewska Magdalena A, Martin-Malpartida Pau, Maisuradze Luka, Macias Maria J, Scheraga Harold A
Abstract excerpt
The origins of formation of an intermediate state involved in amyloid formation and ways to prevent it are illustrated with the example of the Formin binding protein 28 (FBP28) WW domain, which folds with biphasic kinetics. Molecular dynamics of protein folding trajectories are used to examine local and global motions and the time dependence of formation of contacts between C(α)s and C(β)s of selected pairs of...
Topics
- Algorithms
- Amyloid
- Carrier Proteins
- Crystallography, X-Ray
- Humans
- Kinetics
- Molecular Dynamics Simulation
- Mutation
- Protein Folding
- Protein Structure, Secondary
- Protein Structure, Tertiary
- Proteins
- Thermodynamics