Article

The mitotic surveillance pathway requires PLK1-dependent 53BP1 displacement from kinetochores

2023-03-27

Abstract excerpt

53BP1 acts at the crossroads between DNA repair and p53-mediated stress response. With its interactor USP28, it is part of the mitotic surveillance pathway (MSP), a sensor that monitors the duration of cell division, promoting p53-dependent cell cycle arrest when a critical time threshold is surpassed. 53BP1 dynamically associates with kinetochores, being recruited during prophase, and then undergoing a time-depen...

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Literature Corpus work: 1a6a3d7d-3212-52cf-b935-178908a3191b
DOI: 10.1101/2023.03.27.534346

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