Cleavage of CAD by caspase-3 determines the cancer cell fate during chemotherapy

Abstract excerpt

<title>Abstract</title> <p>Metabolic heterogeneity resulting from the intrinsic heterogeneity of human tumors has been shown to cause a myriad of adverse outcomes of tumor therapy, including resistance to chemotherapy, but the mechanisms inside remain largely unknown. Here, we found that the de novo pyrimidine synthesis pathway, which we previously identified as crucial for the proliferation of gastric and colon...

Topics

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• Autophagy in Disease and Therapy
• Biochemical and Molecular Research
• Cancer, Hypoxia, and Metabolism
• Cytidine Deaminase
• Disease Susceptibility
• Gene Expression Regulation
• Genetic factors in colorectal cancer
• RNA modifications and cancer

Identifiers and source

Literature Corpus work

1a58e160-6eb7-504c-8244-1e405c8f2811

DOI

10.21203/rs.3.rs-4826976/v1