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CAD Drives Colorectal Cancer Progression through the JAK2/STAT1 Pathway and Correlates with Poor Prognosis

2025-12-30

Abstract excerpt

<title>Abstract</title> <p>Background Colorectal cancer (CRC) is a highly prevalent and lethal malignant tumor that is tightly linked to metabolic reprogramming. Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD) are enzymes involved in purine de novo synthesis that are overexpressed in a variety of tumors. However, the precise role and immunological regulation mechanism of CA...

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Literature Corpus work
0c7dda88-1c8b-59c8-98d8-805df7ef0091
DOI
10.21203/rs.3.rs-8240821/v1
Open publication

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