Article
Executioner caspases and CAD are essential for mutagenesis induced by TRAIL or vincristine.
Cell death & disease - 5 Oct 2017
Miles Mark A, Hawkins Christine J
Abstract excerpt
Chemotherapy drugs interfere with cellular processes to generate genotoxic lesions that activate cell death pathways. Sustained DNA damage induced by these drugs can provoke mutations in surviving non-cancerous cells, potentially increasing the risk of therapy-related cancers. Ligation of death receptors by ligands such as TRAIL, and subsequent activation of extrinsic apoptotic pathways, also provokes mutations....
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