Article

Icaritin suppresses CAD-mediated liver cancer development by targeting miR-18b-5p in a xenograft mouse model

2025-11-17

Abstract excerpt

<title>Abstract</title> <p> Cancer cells show abnormal nucleotide metabolism and prefer the <italic>de novo</italic> synthesis pathway. As the key enzymes, Carbamoyl-phosphate synthetase 2 (CAD) is overactivated in cancer and promotes pyrimidine <italic>de novo</italic> synthesis, supplying cancer cells with DNA and RNA biosynthesis precursors. Therefore, the development of drugs targeting CAD might inhibit...

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Literature Corpus work: c15c24e2-e31f-5388-968b-bccc2a12c6c9
DOI: 10.21203/rs.3.rs-7606192/v1

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