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Transcription Factor CUTL1 Is a Negative Regulator of Drug Resistance in Gastric Cancer

20 Dec 2012

Abstract excerpt

Gastric cancer is one of the leading causes of malignancy-related mortality worldwide, and drug resistance hampered the clinical efficacy of chemotherapy. To better understand the molecular mechanism causing drug resistance, we previously established an isogenic pair of doxorubicin-sensitive and -resistant gastric cancer cell lines, SGC7901 and SGC7901/ADR cells. Here, we investigated how modulation of CUTL1...

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PMID: 23255599
DOI: 10.1074/jbc.m112.345942

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