Article

Aging-Associated Decline in Macrophage STAT6-OXPHOS Programs Promotes Tumor-Like Multinucleated Syncytia

2026-05-21

Abstract excerpt

<h4>ABSTRACT</h4> Aging can alter macrophage functions through changes in intracellular processing, mitochondrial activity, and chronic inflammatory activation; however, whether aging-associated macrophage deregulation contributes to tumor-associated multinucleated syncytial formation remains poorly understood. Here, we investigated the role of aging macrophages in promoting tumor-like multinucleated syncytia and...

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Literature Corpus work: 1a57c9bd-2634-537f-b15b-3b958c4ceba9
DOI: 10.64898/2026.05.18.726012

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