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Article

Reprogramming the aging ovarian microenvironment via mitochondrial sharing and structural remodeling

16 Aug 2025

Abstract excerpt

Rationale: Mitochondrial dysfunction in ovarian granulosa cells (GCs) and cumulus cells (CCs) is a defining feature of reproductive aging, contributing to impaired oocyte quality and reduced fertility.This study investigates whether enhancing cytoskeletal dynamics or promoting structural contact between cells can restore mitochondrial function and mitigate ovarian aging.Methods: Mitochondrial exchange was...

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Share to Genetics, Aging, and Longevity in Model Organisms
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PMID: 40963898
DOI: 10.7150/thno.119957

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