Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MFN2 contributes to metabolic disorders and inflammation in the aging of rat chondrocytes and osteoarthritis

19 May 2020

Abstract excerpt

OBJECTIVE: Metabolic disorders and inflammation of chondrocytes are major pathological changes in aging cells and osteoarthritis (OA). Recent studies demonstrated age-related mitochondrial dysfunction may be a key contributing factor in the development of OA. Mitofusin 2 (MFN2) is a key regulator of mitochondrial fusion, cell metabolism, autophagy and apoptosis. This study was performed to ascertain whether MFN2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to Mitochondrial Function and Pathology
Share to Osteoarthritis Treatment and Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32416221
DOI: 10.1016/j.joca.2019.11.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MFN2 contributes to metabolic disorders and inflammation in the aging of rat chondrocytes and osteoarthritisPMID 32416221Read ↗

The role and intervention of mitochondrial metabolism in osteoarthritisSemantic proximity Read ↗

Advances in the study of mitophagy in osteoarthritisSemantic proximity Read ↗

Pink1-Mediated Chondrocytic Mitophagy Contributes to Cartilage Degeneration in OsteoarthritisSemantic proximity Read ↗

Fasting activates optineurin-mediated mitophagy in chondrocytes to protect against osteoarthritisSemantic proximity Read ↗

Targeted activation on Bnip3 enhances mitophagy to prevent the progression of osteoarthritisSemantic proximity Read ↗

How are Aging and Osteoarthritis Related?Semantic proximity Read ↗

Mitophagy in degenerative joint diseasesSemantic proximity Read ↗

The Balance of MFN2 and OPA1 in Mitochondrial Dynamics, Cellular Homeostasis, and Disease.Semantic proximity Read ↗

The effect of mitochondrial fusion on chondrogenic differentiation of cartilage progenitor/stem cells via Notch2 signal pathwaySemantic proximity Read ↗

Mitochondria: Potential Targets for OsteoarthritisSemantic proximity Read ↗

Targeting Mitophagy as a Potential Therapeutic Approach for Age‐Related Bone DiseasesSemantic proximity Read ↗

The Effect of Mitochondrial Fusion on Chondrogenic Differentiation of Cartilage Progenitor Cells via Notch2 Signal PathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.