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VISTA: an immune regulatory protein checking tumor and immune cells in cancer immunotherapy

29 Jun 2020

Abstract excerpt

VISTA (V-domain immunoglobulin suppressor of T cell activation) is a well-established immune regulatory receptor. However, pre-clinical investigations indicated more complicated influences of VISTA on cancer immunity than previously recognized. Here, we review the current knowledge on the therapeutic phenotypes and molecular mechanisms that underlie the contradictory roles of VISTA in checking anti-cancer immune...

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PMID: 32600443
DOI: 10.1186/s13045-020-00917-y

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