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<i>In vivo</i> CRISPR screens identify novel virulence genes among proteins of unassigned subcellular localization in <i>Toxoplasma</i>

2024-01-28

Abstract excerpt

<h4>ABSTRACT</h4> The research field to identify and characterize virulence genes in Toxoplasma gondii has been dramatically advanced by a series of in vivo CRISPR screens. Although subcellular localizations of thousands of proteins were predicted by the spatial proteomic method called hyperLOPIT, those of more than 1000 proteins remained unassigned and their essentiality in virulence was also unknown. In this...

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Literature Corpus work
010e7865-c311-5b35-9d47-b8b2c16c5dda
DOI
10.1101/2024.01.28.577556
Open publication

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