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LeishIF4E1 Deletion Affects the Promastigote Proteome, Morphology, and Infectivity

12 Nov 2019

Abstract excerpt

Leishmania parasites are the causative agents of a broad spectrum of diseases. The parasites migrate between sand-fly vectors and mammalian hosts, adapting to changing environments by driving a regulated program of gene expression, with translation regulation playing a key role. The leishmanias encode six different paralogs of eIF4E, the cap-binding translation initiation factor. Since these vary in function,...

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PMID: 31722993
DOI: 10.1128/msphere.00625-19

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