Article

Retinal degeneration in a mouse model of CRB1 disease rescued by the photoreceptor-specific <i>CRB1-B</i> isoform

2026-08-11

Abstract excerpt

Many genes involved in inherited diseases produce alternate mRNA isoforms that remain poorly characterized. Functional assessment of these isoforms could therefore unlock new insights into disease pathobiology or treatment. Here we investigated the function of the newly discovered “B” isoform of CRB1 , a gene implicated in inherited retinal degenerations. CRB1-B is the most abundant retinal isoform, and differs...

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Literature Corpus work: 11443978-5413-5514-aea1-17575887ed57
DOI: 10.64898/2026.08.05.743134

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