Convergent Evolution of Calcineurin Pathway Roles in Thermotolerance and Virulence in<i>Candida glabrata</i>

Abstract excerpt

Candida glabrata is an emerging human fungal pathogen that is frequently drug tolerant, resulting in difficulties in treatment and a higher mortality in immunocompromised patients. The calcium-activated protein phosphatase calcineurin plays critical roles in controlling drug tolerance, hyphal growth, and virulence in diverse fungal pathogens via distinct mechanisms involving survival in serum or growth at host...

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