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Article

Asparagine synthetase: Function, structure, and role in disease.

The Journal of biological chemistry - 8 Dec 2017

Lomelino Carrie L, Andring Jacob T, McKenna Robert, Kilberg Michael S

Abstract excerpt

Asparagine synthetase (ASNS) converts aspartate and glutamine to asparagine and glutamate in an ATP-dependent reaction. ASNS is present in most, if not all, mammalian organs, but varies widely in basal expression. Human ASNS activity is highly responsive to cellular stress, primarily by increased transcription from a single gene located on chromosome 7. Elevated ASNS protein expression is associated with...

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Identifiers

PMID: 29084849
DOI: 10.1074/jbc.R117.819060
PMCID: PMC5723983

Genes

ASNS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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