Article

Replication Stress Tolerance in Adult T-Cell Leukemia

2026-08-10

Abstract excerpt

Replication stress (RS) represents a major vulnerability of cancer cells treated with nu-cleoside analogs and related antimetabolites; however, tumors frequently acquire tol-erance mechanisms that permit survival despite persistent DNA lesions. This review examines molecular determinants of RS tolerance, focusing on human T-cell leukemia virus type 1 (HTLV-1)–mediated adult T-cell leukemia/lymphoma (ATL) as a mode...

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Literature Corpus work: 1988c63c-185b-5e12-a3f5-0dc28b3b6e6a
DOI: 10.20944/preprints202608.0587.v1

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