NF1 modulates microtubule repair and sensitivity to antibody-drug conjugates

Abstract excerpt

Antibody-Drug Conjugates (ADC) have revolutionized the treatment of several tumors, and extensive research is being devoted to the identification of predictive biomarkers. These are particularly sought after in fields, like breast cancer, in which multiple ADCs with identical target but different payloads have been approved. NF1 is a tumor suppressor widely mutated across several cancers, best characterized as an...

Topics

Open a Topic to create a Post that cites this publication.

• Microtubule and mitosis dynamics
• Cancer-related Molecular Pathways
• Genetic Predisposition to Disease
• Germ-Line Mutation
• Occupational and environmental lung diseases
• Protein Degradation and Inhibitors
• Sarcoma Diagnosis and Treatment
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

572b1f43-0ed4-505b-8fcf-36df71aef77f

DOI

10.1101/2023.12.06.569572