Novel (1S,3R)-RSL3-Encapsulated Polyunsaturated Fatty Acid Rich Liposomes Sensitise Multiple Myeloma Cells to Ferroptosis-Mediated Cell Death

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Multiple myeloma (MM) is an incurable malignancy of plasma cells that accounts for 10% of all haematological malignancies diagnosed worldwide. The poor outcome of patients with MM highlights the ongoing need for novel treatment strategies. Ferroptosis is a recently-characterised form of non-apoptotic programmed cell death. Phospholipids (PLs) containing polyunsa...

Topics

Open a Topic to create a Post that cites this publication.

• Autophagy in Disease and Therapy
• Cancer, Lipids, and Metabolism
• Drug Transport and Resistance Mechanisms
• Epigenetics and DNA Methylation
• Ferroptosis and cancer prognosis
• Histone Deacetylase Inhibitors Research
• Multiple Myeloma Research and Treatments
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

196c7120-b04d-5a59-a6c8-c35b3430e6b6

DOI

10.21203/rs.3.rs-6587955/v1