Activation of lysosomal iron triggers ferroptosis in cancer

Abstract excerpt

<title>Abstract</title> <p>Iron catalyses the oxidation of lipids in biological membranes and promotes a form of cell death referred to as ferroptosis^1-3. Identifying where this chemistry takes place in the cell can inform the design of drugs capable of inducing or inhibiting ferroptosis in various disease-relevant settings. Whereas genetic approaches have revealed underlying mechanisms of lipid peroxi...

Topics

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• Cancer, Lipids, and Metabolism
• Cancer-related gene regulation
• Cancer-related molecular mechanisms research
• Drug Transport and Resistance Mechanisms
• Extracellular vesicles in disease
• Ferroptosis and cancer prognosis
• Heme Oxygenase-1 and Carbon Monoxide
• RNA modifications and cancer

Identifiers and source

Literature Corpus work

4794ae13-c9a2-5a8d-b2a7-bf83fa0b8f13

DOI

10.21203/rs.3.rs-4165774/v1