Article

IRF1-mediated thioredoxin (TXN) protects multiple myeloma cells from ferroptosis by regulating polyunsaturated fatty acids (PUFAs) and PUFA-containing phospholipid metabolism

2026-03-10

Abstract excerpt

<title>Abstract</title> <p>Multiple myeloma (MM) is a hematologic malignancy characterized by uncontrolled plasma cell proliferation. Patients with relapsed or refractory MM face poor survival, highlighting the need for novel therapeutic targets. Ferroptosis, an iron-dependent form of regulated cell death, is governed by a complex network of enzymes, proteins, pathways, and organelles, and has been implicated in...

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Literature Corpus work: f29d50e8-0900-55e7-b71d-6809960387ff
DOI: 10.21203/rs.3.rs-8988709/v1

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