Article

Single Nuclei Sequencing Reveals Intratumoral Cellular Heterogeneity and Replication Stress in Adrenocortical Carcinoma

2024-10-02

Abstract excerpt

<h4>ABSTRACT</h4> Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a poor prognosis and limited treatment options. Bulk genomic characterization of ACC has not yielded obvious therapeutic or immunotherapeutic targets, yet novel therapies are needed. We hypothesized that elucidating the intratumoral cellular heterogeneity by single nuclei RNA sequencing analyses would yield insights into potentia...

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Literature Corpus work: 1955fa3f-46ee-5c96-9024-f446b8f6e65c
DOI: 10.1101/2024.09.30.615695

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