Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma.

doi:10.1016/j.ccell.2016.04.002

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Article

Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma.

Cancer cell - 9 May 2016

Zheng Siyuan, Cherniack Andrew D, Dewal Ninad, Moffitt Richard A, Danilova Ludmila, Murray Bradley A, Lerario Antonio M, Else Tobias, Knijnenburg Theo A, Ciriello Giovanni, Kim Seungchan, Assie Guillaume, Morozova Olena, Akbani Rehan, Shih Juliann, Hoadley Katherine A, Choueiri Toni K, Waldmann Jens, Mete Ozgur, Robertson A Gordon, Wu Hsin-Ta, Raphael Benjamin J, Shao Lina, Meyerson Matthew, Demeure Michael J, Beuschlein Felix, Gill Anthony J, Sidhu Stan B, Almeida Madson Q, Fragoso Maria C B V, Cope Leslie M, Kebebew Electron, Habra Mouhammed A, Whitsett Timothy G, Bussey Kimberly J, Rainey William E, Asa Sylvia L, Bertherat Jérôme, Fassnacht Martin, Wheeler David A, Hammer Gary D, Giordano Thomas J, Verhaak Roel G W

Abstract excerpt

We describe a comprehensive genomic characterization of adrenocortical carcinoma (ACC). Using this dataset, we expand the catalogue of known ACC driver genes to include PRKAR1A, RPL22, TERF2, CCNE1, and NF1. Genome wide DNA copy-number analysis revealed frequent occurrence of massive DNA loss followed by whole-genome doubling (WGD), which was associated with aggressive clinical course, suggesting WGD is a...

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Identifiers

PMID: 27165744
DOI: 10.1016/j.ccell.2016.04.002
PMCID: PMC4864952

Genes

CCNE1
RPL22
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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