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MERS-CoV Nsp1 Impairs Cell Viability by Selectively Degrading the mRNAs of Ribosomal Protein Genes and Oxidative Phosphorylation Genes

2021-04-07

Abstract excerpt

Through screening, we found that Middle East respiratory syndrome coronavirus (MERS-CoV) non-structural protein 1 (nsp1) could inhibit cell viability, cell cycle, and cell migration through its endonuclease activity. Transcriptome sequencing revealed that MERS-CoV nsp1 specifically downregulated the mRNAs of ribosomal protein genes, oxidative phosphorylation protein genes, and antigen presentation genes, and upreg...

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Literature Corpus work
037fac80-f191-5d72-bfe6-6ad6976b52d9
DOI
10.2139/ssrn.3821955
Open publication

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