Article

Detection of Activated Receptor Tyrosine Kinases in Human Lung Squamous Cell Carcinoma

2023-02-08

Abstract excerpt

Lung squamous cell carcinoma (LSCC) has a high mutational burden and poor prognosis, even with immunotherapy. In the Lux-Lung 8 trial, afatinib, an epidermal growth factor receptor (EGFR) inhibitor, showed a long-term benefit in 5.3% of patients with LSCC. Because activating mutations of EGFR are rare in LSCC, the response was likely due to wild-type EGFR being activated by an unknown mechanism. All receptor tyros...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 192da9a4-7dc9-51b7-b87d-349ab34191f2
DOI: 10.1101/2023.02.07.527536

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Detection of Activated Receptor Tyrosine Kinases in Human Lung Squamous Cell CarcinomaDOI 10.1101/2023.02.07.527536Read

Adaptive responses to dasatinib-treated lung squamous cell cancer cells harboring DDR2 mutations.Semantic proximity Read

The Role of Proteomics and Phosphoproteomics in the Discovery of Therapeutic Targets and Biomarkers in Acquired EGFR-TKI-Resistant Non-Small Cell Lung Cancer.Semantic proximity Read

Association of ERBB Mutations With Clinical Outcomes of Afatinib- or Erlotinib-Treated Patients With Lung Squamous Cell Carcinoma: Secondary Analysis of the LUX-Lung 8 Randomized Clinical Trial.Semantic proximity Read

Mass Spectrometry Mapping of Epidermal Growth Factor Receptor Phosphorylation Related to Oncogenic Mutations and Tyrosine Kinase Inhibitor SensitivitySemantic proximity Read

Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors.Semantic proximity Read

In-depth Proteomic Analysis of Nonsmall Cell Lung Cancer to Discover Molecular Targets and Candidate BiomarkersSemantic proximity Read

Laser capture microdissection and protein microarray analysis of human non-small cell lung cancer: differential epidermal growth factor receptor (EGPR) phosphorylation events associated with mutated EGFR compared with wild type.Semantic proximity Read

Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS.Semantic proximity Read

Quantitative targeted proteomic analysis of potential markers of tyrosine kinase inhibitor (TKI) sensitivity in EGFR mutated lung adenocarcinoma.Semantic proximity Read

Inhibitor-sensitive FGFR2 and FGFR3 mutations in lung squamous cell carcinoma.Semantic proximity Read

Characterizing tyrosine phosphorylation signaling in lung cancer using SH2 profiling.Semantic proximity Read

PLCγ1‑dependent invasion and migration of cells expressing NSCLC‑associated EGFR mutants.Semantic proximity Read