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Article

Characterizing tyrosine phosphorylation signaling in lung cancer using SH2 profiling.

PloS one - 19 Oct 2010

Machida Kazuya, Eschrich Steven, Li Jiannong, Bai Yun, Koomen John, Mayer Bruce J, Haura Eric B

Abstract excerpt

BACKGROUND: Tyrosine kinases drive the proliferation and survival of many human cancers. Thus profiling the global state of tyrosine phosphorylation of a tumor is likely to provide a wealth of information that can be used to classify tumors for prognosis and prediction. However, the comprehensive analysis of tyrosine phosphorylation of large numbers of human cancer specimens is technically challenging using...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 20976048
DOI: 10.1371/journal.pone.0013470
PMCID: PMC2957407

Genes

EGFR
EGF
MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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