Article
Stress deprivation of tendon explants or Tpm3.1 inhibition in tendon cells reduces F-actin to promote a tendinosis-like phenotype.
Molecular biology of the cell - 1 Dec 2022
Inguito Kameron L, Schofield Mandy M, Faghri Arya D, Bloom Ellen T, Heino Marissa, West Valerie C, Ebron Karl Matthew M, Elliott Dawn M, Parreno Justin
Abstract excerpt
Actin is a central mediator between mechanical force and cellular phenotype. In tendons, it is speculated that mechanical stress deprivation regulates gene expression by reducing filamentous (F)-actin. However, the mechanisms regulating tenocyte F-actin remain unclear. Tropomyosins (Tpms) are master regulators of F-actin. There are more than 40 Tpm isoforms, each having the unique capability to stabilize F-actin...
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