Article

Hyperacusis in the Fmr1-KO Mouse Model of Fragile X Syn-drome: The Therapeutic Relevance of Cochlear Alterations and BKCa Channels

2023-06-27

Abstract excerpt

Hyperacusis, i.e., an increased sensitivity to sounds, is described in several neurodevelopmental disorders (NDDs), including Fragile X Syndrome (FXS). The mechanisms underlying hyperacusis in FXS are still largely unknown and effective therapies are lacking. Big conductance calci-um-activated potassium (BKCa) channels have been proposed as a therapeutic target to treat several behavioral disturbances in FXS precl...

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Literature Corpus work: 1924b0c0-b928-5971-8bc4-93efc4099956
DOI: 10.20944/preprints202306.1906.v1

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