Article

Chlorzoxazone, A BKCa Channel Agonist, Rescues The Pathological Phenotypes Of Williams-Beuren Syndrome In A Preclinical Model

2020-12-23

Abstract excerpt

<h4>ABSTRACT</h4> Williams-Beuren syndrome (WBS) is a rare developmental disorder caused by the deletion of a 1.5 Mb region in chromosome 7 (7q11.23). WBS has been recently modelled by a mutant mouse line having a complete deletion (CD) of the equivalent locus on mouse chromosome 5, thus resembling the genetic defect found in WBS patients. CD mice have been shown to have physical and neurobehavioral abnormalities...

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Literature Corpus work: ca52b7b1-5f21-5a68-9dd0-b355251c52b4
DOI: 10.1101/2020.12.22.423977

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