Article

Multi-omic insights from a multi-ancestry genome-wide meta-analysis of ankylosing spondylitis reveal novel pathways of disease susceptibility

2025-07-14

Abstract excerpt

<title>Abstract</title> <p>We report the largest genome-wide association study meta-analysis in ankylosing spondylitis (AS) to date (25,645 cases, 71,224 controls), identifying 27 novel loci and 86 independent genetic associations. Variations in <italic>FUT2</italic> (non-secretor status) and <italic>ABO</italic> (blood group A) increase AS risk, with Mendelian randomisation (MR) linking non-secretor status to in...

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Literature Corpus work: 192116d1-a4c3-5d05-b7bd-4900f571d6b6
DOI: 10.21203/rs.3.rs-6917334/v1

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