Article
Molecular profiling of endometrial carcinoma precursor, primary and metastatic lesions suggests different targets for treatment in obese compared to non-obese patients.
Oncotarget - 20 Jan 2015
Berg Anna, Hoivik Erling A, Mjøs Siv, Holst Frederik, Werner Henrica M J, Tangen Ingvild L, Taylor-Weiner Amaro, Gibson William J, Kusonmano Kanthida, Wik Elisabeth, Trovik Jone, Halle Mari K, Øyan Anne M, Kalland Karl-Henning, Cherniack Andrew D, Beroukhim Rameen, Stefansson Ingunn, Mills Gordon B, Krakstad Camilla, Salvesen Helga B
Abstract excerpt
Obesity is linked to increased incidence of endometrioid endometrial cancer (EEC) and complex atypical hyperplasia (CAH). We here explore pattern and sequence of molecular alterations characterizing endometrial carcinogenesis in general and related to body mass index (BMI), to improve diagnostic stratification and treatment strategies. We performed molecular characterization of 729 prospectively collected EEC and...
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