Article

Integrative mRNA–miRNA Profiling of mTOR Pathway Dysregulation in High-Grade Serous Ovarian Carcinoma

2026-02-09

Abstract excerpt

<h4>Introduction: </h4> & Background: High-grade serous ovarian carcinoma (HGSOC) is notorious for its poor prognosis owing to its inherent biological aggressiveness and development of chemoresistance. The mechanistic target of rapamycin (mTOR) pathway is dysregulated in 55% of epithelial ovarian cancer, representing an appealing therapeutic target. To date, the clinical trials of mTOR inhibitors have shown mo...

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Literature Corpus work: 8d98fe1f-392a-589f-9dbb-398e9aa350d5
DOI: 10.20944/preprints202602.0684.v1

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