Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Repair of UVB-induced DNA damage is reduced in melanoma due to low XPC and global genome repair.

Oncotarget - 20 Sept 2016

Budden Timothy, Davey Ryan J, Vilain Ricardo E, Ashton Katie A, Braye Stephen G, Beveridge Natalie J, Bowden Nikola A

Abstract excerpt

UVB exposure leads to DNA damage, which when unrepaired induces C>T transitions. These mutations are found throughout the melanoma genome, particularly in non-transcribed regions. The global genome repair (GGR) branch of nucleotide excision repair (NER) is responsible for repairing UV-induced DNA damage across non-transcribed and silent regions of the genome. This study aimed to examine the relationship between...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biopsy
Share to Cell Cycle
Share to DNA Damage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Melanocytes

Share to Melanoma

Share to Skin Neoplasms

Share to Ultraviolet Rays

Source

Open in PubMed Open full text

Identifiers

PMID: 27487145
DOI: 10.18632/oncotarget.10902
PMCID: PMC5308628

Genes

XPC
DDB1
DDB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Repair of UVB-induced DNA damage is reduced in melanoma due to low XPC and global genome repair.PMID 27487145Read ↗

Skin Photodamage and Melanomagenesis: A Comprehensive ReviewSemantic proximity Read ↗

The role of altered nucleotide excision repair and UVB-induced DNA damage in melanomagenesis.Semantic proximity Read ↗

Multiple interaction nodes define the postreplication repair response to UV-induced DNA damage that is defective in melanomas and correlated with UV signature mutation load.Semantic proximity Read ↗

Further assessment of exome-wide UVR footprints in melanoma and their possible relevance.Semantic proximity Read ↗

Oxidative Stress and Genotoxicity in Melanoma Induction: Impact on Repair Rather Than Formation of DNA Damage?Semantic proximity Read ↗

Deciphering UV‐induced DNA Damage Responses to Prevent and Treat Skin CancerSemantic proximity Read ↗

Ultraviolet light and melanoma.Semantic proximity Read ↗

DNA damage and repair in melanoma and non-melanoma skin cancer.Semantic proximity Read ↗

UV damage, DNA repair and skin carcinogenesisSemantic proximity Read ↗

Genomic mutation landscape of skin cancers from DNA repair-deficient xeroderma pigmentosum patients.Semantic proximity Read ↗

Ultraviolet radiation modulates DNA methylation in melanocytesSemantic proximity Read ↗

Cutaneous and acral melanoma cross-OMICs reveals prognostic cancer drivers associated with pathobiology and ultraviolet exposureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.