Article

SynPred: Prediction of Drug Combination Effects in Cancer using Full-Agreement Synergy Metrics and Deep Learning

2021-04-14

Abstract excerpt

High-throughput screening technologies continues to produce large amounts of multiomics data from different populations and cell types for various diseases, such as cancer. However, analysis of such data encounters difficulties due to cancer heterogeneity, further exacerbated by human biological complexity and genomic variability. There is a need to redefine the drug discovery development pipeline, bringing an Art...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 18a3b8c5-cfc4-5790-b441-7c5a22377681
DOI: 10.20944/preprints202104.0395.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SynPred: Prediction of Drug Combination Effects in Cancer using Full-Agreement Synergy Metrics and Deep LearningDOI 10.20944/preprints202104.0395.v1Read

SynSimPred: Leveraging Cell Line Similarities for Drug Combination Synergy PredictionSemantic proximity Read

MatchMaker: A Deep Learning Framework for Drug Synergy PredictionSemantic proximity Read

Pisces: A multi-modal data augmentation approach for drug combination synergy predictionSemantic proximity Read

A cancer pharmacogenomic screen powering crowd-sourced advancement of drug combination predictionSemantic proximity Read

Methods for High-Throughput Drug Combination Screening and Synergy ScoringSemantic proximity Read

Explainable machine learning prediction of synergistic drug combinations for precision cancer medicineSemantic proximity Read

SYNERGxDB: an integrative pharmacogenomic portal to identify synergistic drug combinations for precision oncology.Semantic proximity Read

A statistical framework for defining synergistic anticancer drug interactionsSemantic proximity Read

TranSynergy: Mechanism-Driven Interpretable Deep Neural Network for the Synergistic Prediction and Pathway Deconvolution of Drug CombinationsSemantic proximity Read

One-Hot News: Drug Synergy Models Shortcut Molecular FeaturesSemantic proximity Read

From Cell-Lines to Cancer Patients: Personalized Drug Synergy PredictionSemantic proximity Read

Computational Advancements in Cancer Combination Therapy PredictionSemantic proximity Read