Back to search

Article

One-Hot News: Drug Synergy Models Shortcut Molecular Features

2025-04-24

Abstract excerpt

Combinatorial drug therapy holds great promise for tackling complex diseases, but the vast number of possible drug combinations makes exhaustive experimental testing infeasible. Computational models have been developed to guide experimental screens by assigning synergy scores to drug pair–cell line combinations, where they take input structural and chemical information on drugs and molecular features of cell lines...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
56b65f98-d586-5bb6-a9ab-afffe4ef6ead
DOI
10.1101/2025.04.18.649584
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
One-Hot News: Drug Synergy Models Shortcut Molecular FeaturesDOI 10.1101/2025.04.18.649584
From Cell-Lines to Cancer Patients: Personalized Drug Synergy PredictionSemantic proximity
MatchMaker: A Deep Learning Framework for Drug Synergy PredictionSemantic proximity
SynVerse: A Framework for Systematic Evaluation of Deep Learning Based Drug Synergy Prediction ModelsSemantic proximity
Building A Unified Model for Drug Synergy Analysis Powered by Large Language ModelsSemantic proximity
SynPred: Prediction of Drug Combination Effects in Cancer using Full-Agreement Synergy Metrics and Deep LearningSemantic proximity
Building A Foundation Model for Drug Synergy Analysis Powered by Large Language ModelsSemantic proximity
Pisces: A multi-modal data augmentation approach for drug combination synergy predictionSemantic proximity
Predicting Drug Response and Synergy Using a Deep Learning Model of Human Cancer Cells.Semantic proximity
SynSimPred: Leveraging Cell Line Similarities for Drug Combination Synergy PredictionSemantic proximity
Explainable machine learning prediction of synergistic drug combinations for precision cancer medicineSemantic proximity
A cancer pharmacogenomic screen powering crowd-sourced advancement of drug combination predictionSemantic proximity
A systematic evaluation of deep learning methods for the prediction of drug synergy in cancerSemantic proximity
Select a neighboring publication to make it the new centre.