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Article

Comparative transcriptome analysis of isogenic cell line models and primary cancers links capicua ( CIC ) loss to activation of the MAPK signalling cascade

15 Mar 2017

Abstract excerpt

CIC encodes a transcriptional repressor, capicua (CIC), whose disrupted activity appears to be involved in several cancer types, including type I low-grade gliomas (LGGs) and stomach adenocarcinomas (STADs). To explore human CIC's transcriptional network in an isogenic background, we developed novel isogenic CIC knockout cell lines as model systems, and used these in transcriptome analyses to study the...

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PMID: 28295365
DOI: 10.1002/path.4894

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