Article

Indirect CRISPR screening with photoconversion revealed key factors of drug resistance with cell–cell interactions

2022-07-15

Abstract excerpt

Comprehensive screenings to clarify indirect cell–cell interactions, such as those in the tumor microenvironment, especially comprehensive assessments of supporting cells’ effects, are challenging. Therefore, in this study, indirect CRISPR screening for drug resistance with cell–cell interactions was invented. The photoconvertible fluorescent protein Dendra2 was inducted to determine the drug resistance responsibl...

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Literature Corpus work: 185b1ea0-0e5f-5594-a630-d5f2ca3692e1
DOI: 10.1101/2022.07.15.500173

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