Article

Functional Overlap of Inborn Errors of Immunity and Metabolism Genes Define T Cell Immunometabolic Vulnerabilities

2023-01-24

Abstract excerpt

<h4>SUMMARY</h4> Inborn Errors of Metabolism (IEM) and Immunity (IEI) are Mendelian diseases in which complex phenotypes and patient rarity can limit clinical annotations. Few genes are assigned to both IEM and IEI, but immunometabolic demands suggest functional overlap is underestimated. We applied CRISPR screens to test IEM genes for immunologic roles and IEI genes for metabolic effects and found considerable c...

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Literature Corpus work: d9bd7bc7-a686-5969-ab91-6be0257b0862
DOI: 10.1101/2023.01.24.525419

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