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Article

Optimization of the <i>TeraTox</i> assay for preclinical teratogenicity assessment

2021-07-07

Abstract excerpt

Current animal-free methods to assess teratogenicity of drugs under development still deliver high numbers of false negatives, and more sensitive approaches of toxicity prediction are required. To address this issue, we characterized the TeraTox test, a newly developed multi-lineage differentiation assay for human teratogenicity prediction using 3D human induced pluripotent stem cells. TeraTox produces as primar...

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Identifiers and source

Literature Corpus work
18047aa5-4c33-559c-86e0-dca0d4e6efaf
DOI
10.1101/2021.07.06.451364
Open publication

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Optimization of the <i>TeraTox</i> assay for preclinical teratogenicity assessmentDOI 10.1101/2021.07.06.451364
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