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A novel human pluripotent stem cell-based assay to predict developmental toxicity

22 Jul 2020

Abstract excerpt

There is a great need for novel in vitro methods to predict human developmental toxicity to comply with the 3R principles and to improve human safety. Human-induced pluripotent stem cells (hiPSC) are ideal for the development of such methods, because they are easy to retrieve by conversion of adult somatic cells and can differentiate into most cell types of the body. Advanced three-dimensional (3D) cultures of...

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PMID: 32700165
DOI: 10.1007/s00204-020-02856-6

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