Article

Prediction of broad chemical toxicities using induced pluripotent stem cells and gene networks by transfer learning from embryonic stem cell data

2021-11-05

Abstract excerpt

<h4>SUMMARY</h4> The assessment of toxic chemicals using animals has limited applicability to humans. Moreover, from the perspective of animal protection, effective alternatives are also desired. Previously, we developed a method that combines developmental toxicity testing based on undifferentiated human embryonic stem (ES) cells (KhES-3) and gene networks. We showed that ≥ 95% accurate predictions could be achi...

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Literature Corpus work: 245732e6-a4f1-58d0-98dc-d12e76a4cb17
DOI: 10.1101/2021.11.05.466718

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