Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Discovery of runs-of-homozygosity diplotype clusters and their associations with diseases in UK Biobank.

eLife - 21 Jun 2024

Naseri Ardalan, Zhi Degui, Zhang Shaojie

Abstract excerpt

Runs-of-homozygosity (ROH) segments, contiguous homozygous regions in a genome were traditionally linked to families and inbred populations. However, a growing literature suggests that ROHs are ubiquitous in outbred populations. Still, most existing genetic studies of ROH in populations are limited to aggregated ROH content across the genome, which does not offer the resolution for mapping causal loci. This...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Specimen Banks
Share to COVID-19
Share to Genome, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Homozygote

Share to SARS-CoV-2

Share to UK Biobank

Share to United Kingdom

Source

Open in PubMed Open full text

Identifiers

PMID: 38905121
DOI: 10.7554/eLife.81698
PMCID: PMC11249732

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Discovery of runs-of-homozygosity diplotype clusters and their associations with diseases in UK Biobank.PMID 38905121Read ↗

Discovery of runs-of-homozygosity diplotype clusters and their associations with diseases in UK BiobankSemantic proximity Read ↗

Ancestry-dependent Enrichment of Deleterious Homozygotes in Runs of HomozygositySemantic proximity Read ↗

H3M2: detection of runs of homozygosity from whole-exome sequencing data.Semantic proximity Read ↗

Improved Diagnosis of Rare Disease Patients through Systematic Detection of Runs of Homozygosity.Semantic proximity Read ↗

Genetic diversity and runs of homozygosity (ROH): A portrait of the quantitative academic publication dynamic and scientific metadataSemantic proximity Read ↗

Genomic patterns of homozygosity in worldwide human populations.Semantic proximity Read ↗

DASH: a method for identical-by-descent haplotype mapping uncovers association with recent variation.Semantic proximity Read ↗

Unraveling genotype-phenotype relationships in hereditary hemochromatosis through integrated biobank data analysis.Semantic proximity Read ↗

Assessing runs of Homozygosity: a comparison of SNP Array and whole genome sequence low coverage data.Semantic proximity Read ↗

Combinatorial Conflicting Homozygosity (CCH) analysis enables the rapid identification of shared genomic regions in the presence of multiple phenocopies.Semantic proximity Read ↗

FounderRare: A Novel Statistical Package to Identify Rare Variants in Complex DiseasesSemantic proximity Read ↗

Genome-Wide Assessment of Runs of Homozygosity by Whole-Genome Sequencing in Diverse Horse Breeds Worldwide.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.