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Article

Transcriptional regulation and alternative splicing cooperate in muscle fiber-type specification in flies and mammals

19 Oct 2013

Abstract excerpt

Muscles coordinate body movements throughout the animal kingdom. Each skeletal muscle is built of large, multi-nucleated cells, called myofibers, which are classified into several functionally distinct types. The typical fiber-type composition of each muscle arises during development, and in mammals is extensively adjusted in response to postnatal exercise. Understanding how functionally distinct muscle...

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PMID: 24145055
DOI: 10.1016/j.yexcr.2013.10.007

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