Article

“Genetic and chemical disruption of Amyloid Precursor Protein processing impairs zebrafish sleep maintenance”

2022-06-10

Abstract excerpt

Amyloid precursor protein (APP) is a brain-rich, single pass transmembrane protein that is proteolytically processed into multiple products, including Amyloid-beta (Aβ), a major driver of Alzheimer’s disease (AD). Although both over-expression of APP, as in mouse models used to study AD, and exogenously delivered Aβ lead to changes in sleep behaviors, whether APP processing plays an endogenous role in regulating s...

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Literature Corpus work: e5daae5d-bdc9-5221-8050-acffc2128fb2
DOI: 10.1101/2022.06.08.495312

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