Article

Not All Sleep Loss is Equal: A Comprehensive Evaluation of Rodent Models, Their Neurobiological Validity, and Translational Relevance to Neurological Disease

2026-04-18

Abstract excerpt

Not all sleep loss is the same, and failing to recognise this is the biggest barrier to advancing research in sleep and neurological diseases. This review systematically compares nine rodent sleep deprivation paradigms: gentle handling, the multiple platform method and its variants, the disk-over-water method, the Unpredictable Chronic Sleep Deprivation (UCSD) paradigm developed in our laboratory, novel object int...

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Literature Corpus work: 6fc01b7e-d8a4-52f3-a8c8-337619480894
DOI: 10.20944/preprints202604.1305.v1

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