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Assessing the virulence of Cryptococcus neoformans causing meningitis in HIV infected and uninfected patients in Vietnam.

Medical mycology - 10 Nov 2020

Thanh Lam Tuan, Toffaletti Dena L, Tenor Jennifer L, Giamberardino Charles, Sempowski Gregory D, Asfaw Yohannes, Phan Hai Trieu, Van Duong Anh, Trinh Nguyen Mai, Thwaites Guy E, Ashton Philip M, Chau Nguyen Va Vinh, Baker Stephen G, Perfect John R, Day Jeremy N

Abstract excerpt

We previously observed a substantial burden of cryptococcal meningitis in Vietnam atypically arising in individuals who are uninfected with human immunodeficiency virus (HIV). This disease was associated with a single genotype of Cryptococcus neoformans (sequence type [ST]5), which was significantly less common in HIV-infected individuals. Aiming to compare the phenotypic characteristics of ST5 and non-ST5 C....

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PMID: 32196550
DOI: 10.1093/mmy/myaa013
PMCID: PMC7657091

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