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Article

FKBP5 polymorphisms induce differential glucocorticoid responsiveness in primary CNS cells - First insights from novel humanized mice.

The European journal of neuroscience - 1 Jan 2021

Nold Verena, Richter Nadine, Hengerer Bastian, Kolassa Iris-Tatjana, Allers Kelly Ann

Abstract excerpt

The brain is a central hub for integration of internal and external conditions and, thus, a regulator of the stress response. Glucocorticoids are the essential communicators of this response. Aberrations in glucocorticoid signaling are a common symptom in patients with psychiatric disorders. The gene FKBP5 encodes a chaperone protein that functionally inhibits glucocorticoid signaling and, thus, contributes to...

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PMID: 33030232
DOI: 10.1111/ejn.14999
PMCID: PMC7894319

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