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Article

Early adversity as the prototype gene × environment interaction in mental disorders?

Pharmacology, biochemistry, and behavior - 1 Apr 2022

Martins Jade, Yusupov Natan, Binder Elisabeth B, Brückl Tanja M, Czamara Darina

Abstract excerpt

Childhood adversity (CA) as a significant stressor has consistently been associated with the development of mental disorders. The interaction between CA and genetic variants has been proposed to play a substantial role in disease etiology. In this review, we focus on the gene by environment (GxE) paradigm, its background and interpretation and stress the necessity of its implementation in psychiatric research....

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Source

Identifiers

PMID: 35271857
DOI: 10.1016/j.pbb.2022.173371

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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