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Article

Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency.

PloS one - 1 Jan 2014

Sabbagh Jonathan J, O'Leary John C, Blair Laura J, Klengel Torsten, Nordhues Bryce A, Fontaine Sarah N, Binder Elisabeth B, Dickey Chad A

Abstract excerpt

Single nucleotide polymorphisms (SNPs) in the FK506 binding protein 5 (FKBP5) gene combine with traumatic events to increase risk for post-traumatic stress and major depressive disorders (PTSD and MDD). These SNPs increase FKBP51 protein expression through a mechanism involving demethylation of the gene and altered glucocorticoid signaling. Aged animals also display elevated FKBP51 levels, which contribute to...

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Source

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Identifiers

PMID: 25191701
DOI: 10.1371/journal.pone.0107241
PMCID: PMC4156438

Genes

FKBP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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