Article

Tumour mutations in long noncoding RNAs enhance cell fitness

2021-11-07

Abstract excerpt

Long noncoding RNAs (lncRNAs) can act as tumour suppressors or oncogenes to repress/promote tumour cell proliferation via RNA-dependent mechanisms. Recently, genome sequencing has identified elevated densities of tumour somatic single nucleotide variants (SNVs) in lncRNA genes. However, this has been attributed to phenotypically-neutral “passenger” processes, and the existence of positively-selected fitness-alteri...

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Literature Corpus work: 17787c23-b4bb-5325-823f-76a86968e376
DOI: 10.1101/2021.11.06.467555

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